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KMID : 1161420130160110977
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Journal of Medicinal Food
2013 Volume.16 No. 11 p.977 ~ p.983
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2,4-Di-tert-butylphenol from Sweet Potato Protects Against Oxidative Stress in PC12 Cells and in Mice
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Choi Soo-Jung
Kim Jae-Kyeom
Kim Hye-Kyung
Harris Keith
Kim Chang-Ju
Park Gwi-Gun
Park Cheung-Seog
Shin Dong-Hoon
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Abstract
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In this study, the protective effect of sweet potato extract against hydrogen peroxide-induced oxidative stress and cytotoxicity on the pheochromocytoma cell line (PC12) was investigated. The active component of the sweet potato extract was purified and determined to be 2,4-di-tert-butylphenol. The antioxidant capacity of 2,4-di-tert-butylphenol was measured by using 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) radical. To examine the effects of 2,4-di-tert-butylphenol on amyloid-beta peptide (Aβ1-42)-induced learning and memory impairment in mice, in vivo behavioral tests were performed. Administration of 2,4-di-tert-butylphenol increased alternation behavior in mice injected with Aβ1-42. These results suggest that sweet potato extract could be protective against Aβ-induced neurotoxicity, possibly due to the antioxidative capacity of its constituent, 2,4-di-tert-butylphenol.
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KEYWORD
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Alzheimer's disease, amyloid beta peptide, oxidative stress, PC12 cells
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